Paul Ewald is a cancer researcher. He says we're entering a golden era in cancer treatment based on one emerging idea: most cancers are caused by viruses. It's good news, according to Ewald, who says we'll be able to treat cancer preventively, with vaccines. In this hour of To the Best of Our...Read more
Intelligent. Optimistic. Curious.
Episode Archives
Her novel “Bel Canto” was a hit so now novelist Ann Patchett is a star. But back when they were in college, it was her fellow student Lucy Grealy who got treated like a rock star. In this hour of To the Best of Our Knowledge, a look at uncommon friendships. Ann Patchett tells how her...Read more
Walk into the children's section of any bookstore and the magic wands and secret portals almost materialize in front of you. Wizards, witches, demons, time travel, dragons, orphans, orphaned dragons – doesn't anyone know how to write a non-magical book anymore?! In this hour of To the Best of...Read more
Can science conquer death? It may seem like an absurd question, but some people think it's possible. In this hour of To The Best Of Our Knowledge, we'll meet Aubrey de Grey, a maverick English scientist who's identified seven major kinds of molecular and cellular damage. He thinks we can prevent...Read more
It was the best of times for Pattie Boyd. Her modeling career was booming and the sixties were exploding on the London scene. One day she got a call - she'd been cast in a Beatles film. The rest is history. We'll meet the woman who inspired three of the most famous rock songs of all time,...Read more
Is there anything science won’t tackle? The latest question neuroscientists are taking on is, “What makes something beautiful?” We're checking in with the scientists, the philosophers and the artists in this hour.Read more
Take a stroll through a natural history museum these days and you’ll not only see dinosaurs, you’ll smell them. Get a whiff of T-rex’s halitosis, his dinner leftovers, and, well, how should I put this – his droppings, too! In this hour of To the Best of Our Knowledge, museums that tickle your...Read more
James Tiptree Jr. wrote some of the most critically-acclaimed science fiction stories in the 1960's and 1970's....classics like "Houston, Houston, Do You Read?" and "The Women Men Don't See." But James Tiptree was actually the pseudonym of a 61-year-old woman, Alice B. Sheldon. In this hour of...Read more
Well we made it through the anticipated apocalypse.
Now, to say, "Goodbye old year; hello, new."
To help us begin again, we’ve got a collection of stories about putting challenges behind us. About transformation. About coming through hard times into...Read more
Remember those great cars from the Fifties? The Redscare Phantom Witchhunter and the Bongo Beatnik Ferlinghetti TurboHipster? If you don’t recall them rolling off Detroit’s assembly lines, there’s a perfectly good reason. They never existed, except in the imagination of writer and illustrator...Read more
One of this year's big novels is Colson Whitehead's sweeping historical novel, "The Underground Railroad." It's an unflinching look at the experience of slavery, inspired by the classic slave narratives. And being a sci-fi geek, Whitehead also weaves in bits of fantasy, creating an alternative...Read more
Think you know your history? Then, of course, you remember Martin Luther King's famous "If I Had A Hammer" speech. And you know that Joan of Arc was Noah's wife...and she was at rest on Mount Arafat. And you don't need me to remind you that Marie Curie won the Noel Prize for inventing the...Read more
Are you an experimental innovator who works by trial and error and is most creative later in life, like Cezanne? Or are you a conceptual young genius like Picasso? We'll explore a theory that those are the two life cycles of artistic creativity.Read more
What’s the best way to get someone to talk? NPR’s Terry Gross has done more interviewers than just about anyone else in public radio. But she prefers to talk to them long distance, with no eye contact. In this hour of To the Best of Our Knowledge, Terry Gross on the art of the interview.Read more
It doesn’t get much more American than a waitress in a diner taking your order. In this hour of To the Best of Our Knowledge, the diner. For some, like painter Edward Hopper, the diner is a muse. For others it’s just a greasy spoon. But have we romanticized the endless cups of coffee and the...Read more
Al Green is often referred to as the minister of L-O-V-E. You know, a couple of candles, a back-rub, and Al Green on the stereo. In 1976, Al Green put all that behind him and became a real minister – the Reverend Al Green of the Full Gospel Tabernacle Church in Memphis, Tennessee. But now he's...Read more
Film on radio? Why not? This hour, join us LIVE from the historic Orpheum Theatre in Madison, Wisconsin, for a special “Wisconsin Film Festival edition” of To The Best of Our Knowledge for film on radio. We’ll talk Dogme with “Italian for Beginners” director, Lone Scherfig. Also, the anti-...Read more
When the Taliban took control of Kabul, many Afghans destroyed their books and TV sets. Belquis Ahmadi’s family left the country when women lost their rights. Today, Ahmadi lives in exile, campaigning for women to play a major role in a new Afghan government. Her story in this...Read more
Magic is an art, a philosophy, and a way of seeing the world. In this hour, we learn magic tricks from a stage magician, travel to India's last magician's colony, explore shamanic magic, and talk with magical novelists Erin Morgenstern (Night Circus) and Deborah Harkness (...Read more
Science and the Search for Meaning: Five Questions, Part Two: What Does Evolution Want?
If there’s one strand of evolutionary theory that sticks in the craw of nearly every religious believer, it’s the idea that human beings are just an evolutionary accident. But...Read more
How far would you go for something to eat? Paris? Mom’s house? The drive-through at Mickey D’s? I bet you wouldn’t swim thousands of miles, from Mexico to the Arctic, just to scarf up mud from the bottom of the ocean. Whales do, and they’ve been doing it every year for eons. In this hour...Read more
Atheists are finally coming out of the closet, and in some cases denouncing religion. Others still crave a sense of the sacred even though they don’t believe in God. Do atheists have something to learn from religion? Why do so many people call themselves "spiritual but not religious"? And...Read more
Governors are slashing state spending, and the President has put some of his own party's favorite programs on the chopping block. But how much of the new austerity is really necessary, and how much is politics? In this hour of To the Best of Our Knowledge, is austerity a dangerous idea? Join...Read more
Bohemians used to hate anything that reeked of money. It destroyed the soul. Now, many self-styled bohemians are reveling in slate shower stalls, Range Rovers, and lava-rock grills. In this hour of To the Best of Our Knowledge, the triumphs of the “Bobo” – the Bourgeois...Read more