Paul Ewald is a cancer researcher. He says we're entering a golden era in cancer treatment based on one emerging idea: most cancers are caused by viruses. It's good news, according to Ewald, who says we'll be able to treat cancer preventively, with vaccines. In this hour of To the Best of Our...Read more
Intelligent. Optimistic. Curious.
Episode Archives
Gore Vidal has a special fondness for the Founding Fathers, especially George Washington. “The others were geniuses. He was not a genius” he says, but “he had a powerful character which got him through the revolution, since he was not much of a general. But he was a great leader.” We’ll talk...Read more
As the Zika virus continues to make headlines, consensus is slowly growing among scientists that it’s showdown time for the mosquito. Time to marshal the technology to wipe them off the face of the earth. Which seems pretty extreme. Doesn’t it?
So, should we bio-...Read more
He was the most surprising Booker Prize winner in years. DBC Pierre had been a con man and a drug addict before he became a writer. Now he’s won one of the world’s great literary prizes. In this hour of To the Best of Our Knowledge we’ll talk with some award-winning writers including DBC...Read more
Physicist Lawrence Krauss says science can finally explain the age-old mystery: How can something come out of nothing? Or, to be more specific, how can the Big Bang pop out of empty space? Krauss also set off an intellectual brawl by saying theologians and philosphers have nothing...Read more
Thousands of the world's languages are disappearing in the wake of globalization. And because language is the DNA of culture, a lost language is a lost culture. Today, stories from the frontlines of the language revitalization movement. Also, Dr. Larry Brilliant's improbable journey from...Read more
We're keepin it surreal this hour with a hallucinatory vortex chock full of innovative fiction. Like Salvador Dali said -- "Surrealism is destructive, but it destroys only what it considers to be shackles limiting our vision." Join us as we expand your vision and melt your mind....Read more
If you think the influence of Shakespeare is confined to the page and the stage, think again. Take starlings, the aggressive European birds who’ve pushed a lot of Native American birds out of their nests. They were introduced by a Shakespeare fanatic, who loosed dozens of them in Central Park....Read more
You know those end of the year lists? Best books, movies, music and so on? This hour, To the Best of Our Knowledge shares the best interviews from 2015. Plus a booklist or two.Read more
A fashion model with prosthetic legs… a musician who can’t hear… a writer who can’t see. Instead of disabled, differently-abled, handicapped – why not better-abled?Read more
Behold the spectacle of epic proportions! The abundant feast laid out! Tribes decked in battle attire!
Yes, friends. It's Super Bowl weekend, and have we got a show for you...Read more
These days it seems we just can’t get enough of it. Over the past few years, luxury spending in the United States has been growing four times faster than overall spending. We’re spending more money on more products and services that we don’t really need – like Evian bottled water and Prada...Read more
It doesn’t get much more American than a waitress in a diner taking your order. In this hour of To the Best of Our Knowledge, the diner. For some, like painter Edward Hopper, the diner is a muse. For others it’s just a greasy spoon. But have we romanticized the endless cups of coffee and the...Read more
Ingrid Betancourt was kidnapped by Marxist rebels in Columbia while in the midst of her presidential campaign. She spent the next six and a half years in captivity chained, humiliated and abused. But her greatest fear was not death. It was losing her humanity. In this hour of To the Best of Our...Read more
Film on radio? Why not? This hour, join us LIVE from the historic Orpheum Theatre in Madison, Wisconsin, for a special “Wisconsin Film Festival edition” of To The Best of Our Knowledge for film on radio. We’ll talk Dogme with “Italian for Beginners” director, Lone Scherfig. Also, the anti-...Read more
Novelist John Updike doesn’t like doing interviews. At least until the interview starts. Then he realizes it’s kind of flattering to talk about himself. Now, he’s written a novel about a famous artist being interviewed. In this hour of To the Best of Our Knowledge, John Updike on why an...Read more
What if our lives were like DVDs? What if we had alternative endings to look forward to, instead of death? We explore our lust for immortality. And we look at the many alternative endings that Ernest Hemingway wrote for his classic novel, "A Farewell to Arms."
Is there anything science won’t tackle? The latest question neuroscientists are taking on is, “What makes something beautiful?” We're checking in with the scientists, the philosophers and the artists in this hour.Read more
Take a stroll through a natural history museum these days and you’ll not only see dinosaurs, you’ll smell them. Get a whiff of T-rex’s halitosis, his dinner leftovers, and, well, how should I put this – his droppings, too! In this hour of To the Best of Our Knowledge, museums that tickle your...Read more
The world of plants can be a dangerous place. Gorgeous monkshood, with stalks of purple blooms can cause delusions and death. A plump cashew can make you miserable if it isn't steamed properly. And aconite, almost indistinguishable from parsley can cause paralysis and stop your beating heart...Read more
You might think that men’s anxiety over baldness is a relatively recent development in the history of civilization. But it’s not. The ancient Romans invented the comb-over and paint-on hair, which has since become spray-on hair. In this hour of To the Best of Our Knowledge we’...Read more
American children grow up playing Pokemon and Yu-Gi-Oh. As adults, they line up for the latest anime movies and hang out in karaoke bars. In other words -- Japanese culture is serious business. So serious that Japan's Prime Minister appointed a "Cool Japan" minister to oversee...Read more
With the emergence of barefoot running, the sport suddenly is red hot again. But barefoot or not, are human bodies really born to run? We'll check in on the science or runner's high this hour, and try to unlock the secrets of the Kenyans - the fastest people on earth. Also, Olympic medalist...Read more
The collapse of the twin towers gave birth to a strange new world. It was a city of fire and dust, rubble crunching under foot and eerie underground rivers. William Langewiesche was the only journalist with unrestricted access to Ground Zero. What he found there was startling, natural, and...Read more